ADVANCES AND CHALLENGES IN CRISPR/CAS-BASED FUNGAL GENOME ENGINEERING FOR SECONDARY METABOLITE PRODUCTION: A REVIEW

Advances and Challenges in CRISPR/Cas-Based Fungal Genome Engineering for Secondary Metabolite Production: A Review

Fungi represent an important source of bioactive secondary metabolites (SMs), which have wide applications in many fields, Accessories including medicine, agriculture, human health, and many other industries.The genes involved in SM biosynthesis are usually clustered adjacent to each other into a region known as a biosynthetic gene cluster (BGC).Th

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High density laminar recordings reveal cell type and layer specific responses to infrared neural stimulation in the rat neocortex

Abstract Infrared neural stimulation has consistently shown that temperature is a critical neuronal state variable.However, a comprehensive understanding of the biophysical background is essential.In this study, using high-density laminar electrode recordings, we investigated the impact of pulsed and continuous-wave infrared illumination on cortica

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